Most sports with highly negatively correlated players (defense vs. offense in NFL, batters vs. pitcher in MLB, etc.) have a default rule on SaberSim that you can find under Rules → Groups:
Check this box to turn this rule on and avoid these negative correlations in your lineups.
Note that because SaberSim builds lineups based on simulations of real games, it’s unlikely to get these types of lineups anyway except on particularly small slates, because it’s simply unlikely for these types of lineups to be what you need to win.
During Late Swap, Quick Swap has an Avoid Opponents setting that stops it from swapping a player in against their own opponent.
